2. Neurological Disease

Neurological Disease

Neurological Disease

Related Products

PDF 88.0 MB

A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-105238
    JHU-75528 947696-17-5 98%
    JHU-75528 is a novel ligand of the cannabinoid receptor (CB1). JHU-75528 can be used in the research of imaging CB1 receptor.
    JHU-75528
  • HY-105253
    PARP-2/1-IN-2 912444-01-0 98%
    PARP-2/1-IN-2 (Compound 4a), the enantiomer of Veliparib (HY-10129), is a potent PARP inhibitor with Kis of 2 and 5 nM against PARP-2 and PARP-1, respectively. PARP-2/1-IN-2 has an EC50 of 3 nM in a cell based assay of PARP activity.
    PARP-2/1-IN-2
  • HY-105297
    BMS-505130 fumarate 859230-84-5 98%
    BMS-505130 (fumarate) is a potent, selective and orally active serotonin transport inhibitor with a Ki for binding to the serotonin transporter of 0.18 nM (Ki for norepinephrine and dopamine transporters of 4.6 and 2.1 μM, respectively). BMS-505130 (fumarate) can be used for the research of neurological disease, such as depression.
    BMS-505130 fumarate
  • HY-105306
    R-1647 3565-47-7 98%
    R-1647 is a haloperidol derivative with antipsychotic effect.
    R-1647
  • HY-105328
    S-14489 153607-44-4 98%
    S-14489 is an orally active selective postsynaptic 5-HT1A receptor antagonist with a pKi of 9.2. S-14489 can act as a 5-HT1A autoreceptor agonist and inhibit striatal 5-hydroxytryptophan accumulation. S-14489 can be used for the research of neurological disease.
    S-14489
  • HY-105330
    SIB 1663 179064-11-0 98%
    SIB 1663 is a conformationally restricted analog of nicotine. SIB-1663 selectively activatedα2β4 and α4β4 human recombinant neuronal nAChRs. SIB 1663 can increase DA and NE release. SIB 1663 can be used for the research of neurological disease.
    SIB 1663
  • HY-105340
    MDL 27266 116114-14-8 98%
    MDL 27266 is an orally active NMDA receptor antagonist with neuroprotective effect. MDL 27266 is a broad-spectrum anticonvulsant agent.
    MDL 27266
  • HY-105353
    CEB-1604 287173-08-4 98%
    CEB-1604 is an NMDA receptor antagonist. CEB-1604 inhibits NMDA-induced currents in oocytes transfected with NMDA receptor isoforms (NR1/NR2A, NR1/NR2B, NR1/NR2C, NR1/NR2D) with IC50 values ranging from 5 to 12 μM. CEB-1604 abolishes NMDA-dependent epileptiform discharges in rat cortical wedge preparations and reduces the depolarizing effects of NMDA. CEB-1604 can be used in the research field of neurological damage diseases.
    CEB-1604
  • HY-105365
    PD 175069 217170-95-1 98%
    PD 175069 is a potent and selective N-type calcium channel antagonist with an IC50 of 0.32 μM. PD 175069 is efficacious in an audiogenic seizure model using DBA/2 mice. PD 175069 can be used for research on neurological conditions such as neuropathic pain and stroke.
    PD 175069
  • HY-105403
    Besonprodil 253450-09-8 98%
    Besonprodil (CI-1041) is a potent NMDA antagonist.
    Besonprodil
  • HY-105410
    OT-7100 174858-27-6 98%
    OT-7100 is an orally active analgesic agent. OT-7100 inhibits hyperalgesia possibly by enhancing adenosinergic neurotransmission in the dorsal horn. OT-7100 can be used for the researches of inflammation, neurological and metabolic disease such as diabetes2].
    OT-7100
  • HY-105413
    L-703717 142326-92-9 98%
    L-703717 is a NMDA receptor antagonist. L-703717 preferentially binds to cerebellar-specific NMDA receptors consisting of a GluRepsilon3 subunit and eventually accumulates in rodent cerebellum. L-703717 can be used for the research of neurological disease.
    L-703717
  • HY-105435
    FR121196 133920-65-7 98%
    FR121196 is a cognitive enhancer, and ameliorates Scopolamine (HY-N0296)-induced memory deficit. FR121196 is an antidementia compound.
    FR121196
  • HY-105436
    FR 113680 126088-92-4 98%
    FR 113680 is a tripeptide substance P antagonist that interacts selectively with the NK1 neurokinin receptor.
    FR 113680
  • HY-105447
    PD 128483 115688-97-6 98%
    PD 128483 is a selective dopamine autoreceptor agonist. PD 128483 can be used for the research of neurological disease.
    PD 128483
  • HY-105450
    GPI-3000 144301-37-1 98%
    GPI-3000 is a NMDA receptor antagonist. GPI-3000 can ameliorate metabolic injury and shows neuroprotective effect. GPI-3000 can be used for the researches of metabolic and neurological disease.
    GPI-3000
  • HY-105458
    BL-2401 151774-56-0 98%
    BL-2401 is an orally active enkephalinase inhibitor. BL-2401 exhibit antinociceptive and antidepressant-like activitiesin association with endogenous opioid systems. BL-2401 can be used for the research of neurological disease.
    BL-2401
  • HY-105462
    MDL 105212A 167261-60-1 98%
    MDL 105212A is a potent and orally active nonpeptide neurokinin receptor (NK-1/NK-2) tachykinin receptor antagonist. MDL 105212A can be used for the researches of inflammation, immunology and neurological disease, such as asthma.
    MDL 105212A
  • HY-105472
    ORG 31433 132031-83-5 98%
    ORG 31433 is an orally active peptide related to the ACTH-(4-9) analog ORG 2766 (HY-P2113). ORG 31433 shows neuroprotective effect.
    ORG 31433
  • HY-105476
    TAN 950A 127607-88-9 98%
    TAN 950A is antifungal amino acid antibiotic. TAN 950A has affinity for three excitatory amino acid (EAA) receptor and can inhibit [3H]AMPA, [3H]kainite and [3H]CPP binding competitively. TAN 950A can be used for the researches of infection and neurological disease.
    TAN 950A
Cat. No. Product Name / Synonyms Application Reactivity