2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-124135
    SB-656104 446020-51-5 98%
    SB-656104 is a potent antagonist of 5-HT7 receptor, with the pKi of 8.70, blocking 5-carboxamidotryptamine (5-CT) stimulated adenylyl cyclase activity.
    SB-656104
  • HY-124152
    3,4-Dephostatin 173043-84-0 98%
    3,4-Dephostatin (Methyl-3,4-dephostatin) is an inhibitor of protein-tyrosine phosphatase (PTPase). 3,4-Dephostatin accelerates nerve growth factor (NGF)-induced neurite formation in PC12h cells. 3,4-Dephostatin sustains the NGF-induced tyrosine phosphorylation of proteins, most prominently that of mitogen-activated protein (MAP) kinase. 3,4-Dephostatin also prolongs epidermal growth factor (EGF)-induced tyrosine phosphorylation and activation of MAP kinase.
    3,4-Dephostatin
  • HY-124160
    JNJ-56022486 2036082-79-6 98%
    JNJ-56022486 is an orally active and potent negative AMPA receptor modulator (Ki=19 nM) selective for?TARP-γ8. JNJ-56022486 is also a TARP-γ8 receptor antagonist, with blood?brain?barrier (BBB) permeability. JNJ-56022486 can be used for research of Epilepsy.
    JNJ-56022486
  • HY-124204
    LY 274614 136109-04-1 98%
    LY 274614 is an orally active, competitive NMDA receptor antagonist. LY 274614 can be used for Neurological Disease study.
    LY 274614
  • HY-124223
    AF-DX 384 methanesulfonate 118290-27-0 98%
    AF-DX 384 (methanesulfonate) is a selective antagonist of M2 and M4 muscarinic acetylcholine receptors (Kis=6.03 and 10 nM, respectively). AF-DX 384 (methanesulfonate) reverses deficits in novel object recognition and passive avoidance in aged rats, as well as in young rats with impairments induced by scopolamine.
    AF-DX 384 methanesulfonate
  • HY-124264
    UBP710 1333111-40-2 98%
    UBP710 is a selective NMDA receptor modulator. UBP710 displays greater activity in potentiating GluN2B-containing receptors than those containing GluN2A.
    UBP710
  • HY-124296
    2C-TFM hydrochloride 159277-13-1 98%
    2C-TFM hydrochloride is a ,5-dimethoxyphenethylamines compound with a para-trifluoromethyl substitution. 2C-TFM hydrochloride is a potent agonist of the 5-HT receptor subtypes 5-HT2A and 5-HT2C.
    2C-TFM hydrochloride
  • HY-124310
    PDE5-IN-6c 1448419-13-3 98%
    PDE5-IN-6c is a potent and selective phosphodiesterase 5A1 (PDE5A1) inhibitor with the potential to inhibit Alzheimer's disease (AD). PDE5-IN-6c exhibits an excellent in vitro IC50 (0.056 nM), demonstrating its potent inhibitory activity. PDE5-IN-6c has improved water solubility, making it a more attractive drug candidate.
    PDE5-IN-6c
  • HY-124320
    Desmethylene paroxetine hydrochloride 1394861-12-1 98%
    Desmethylene paroxetine hydrochloride is a major urinary metabolite of Paroxetine. Paroxetine is a potent serotonin reuptake inhibitor.
    Desmethylene paroxetine hydrochloride
  • HY-124357
    Seproxetine hydrochloride 127685-30-7 98%
    Seproxetine (S-Norfluoxetine) hydrochloride is a selective serotonin reuptake inhibitor (SSRI) that enhances serotonin levels in the brain by specifically inhibiting the serotonin uptake carrier. Seproxetine hydrochloride exhibits strong charge transfer interactions with π-electron acceptors, forming stable complexes that enhance its binding affinity to multiple receptors, including serotonin and dopamine receptors. Seproxetine hydrochloride demonstrates improved biological activity when interacting with charge transfer complexes, leading to increased stability and efficacy in therapeutic applications.
    Seproxetine hydrochloride
  • HY-124367
    25B-NBF hydrochloride 1539266-17-5 98%
    25B-NBF hydrochloride is a highly potent agonist for the 5-HT2C receptor binds human 5-HT2A receptors and rat 5-HT2C receptors with pKi values of 8.57 and 7.73, respectively.
    25B-NBF hydrochloride
  • HY-124372
    JNJ-46356479 1254979-66-2 98%
    JNJ-46356479 is a selective and orally bioavailable mGlu2 receptor positive allosteric modulator (PAM), with the EC50 of 78 nM. JNJ-46356479 shows active in vivo.
    JNJ-46356479
  • HY-124382
    AS1928370 1345614-89-2 98%
    AS1928370 is a novel and central nervous system (CNS) penetrant TRPV1 antagonist and can prevent ligand-induced activation in vivo. AS1928370 is a promising agent for neuropathic pain treatment research.
    AS1928370
  • HY-124406
    A-794282 869802-44-8 98%
    A-794282 is a compound with analgesic activity and is a selective mGlu1 receptor antagonist that significantly reduces pain behaviors in a postoperative pain model, but motor side effects may occur at higher doses.
    A-794282
  • HY-124412
    Paynantheine 4697-66-9 98%
    Paynantheine is an alkaloid with antinociceptive activity, which is found in Mitragyna speciosa. Paynantheine is also a 5-HT1AR and 5-HT2BR agonist that induces lower lip retraction and antinociception in rats.
    Paynantheine
  • HY-124413
    Otosenine 16958-29-5 98%
    Otosenine is a natural pyrrolizidine alkaloid. Otosenine can be isolated from the aerial parts of the golden ragwort, Senecio aureus. Otosenine has spasmolytic and hypotensive properties.
    Otosenine
  • HY-124463
    Epiallopregnanolone 567-01-1 98%
    Epiallopregnanolone (5α,3β-THDOC), a 3β-hydroxy neurosteroid, an antagonist at GABAA receptors and a NMDA receptor enhancer.
    Epiallopregnanolone
  • HY-124467
    Difludiazepam 39080-67-6 98%
    Difludiazepam (Ro 07-4065), a benzodiazepine, has binding affinity (0.613) to GABAA receptors.
    Difludiazepam
  • HY-124539
    ZK 187638 397298-63-4 98%
    ZK 187638 is an AMPA receptor antagonist. ZK 187638 antagonizes the kainate-induced currents in cultured hippocampal neurons with an IC50 of 3.4 μM in a noncompetitive fashion.
    ZK 187638
  • HY-124550
    Sarcophine 55038-27-2 98%
    Sarcophine ((+)-Sarcophine) is a potent glycine receptor (GlyR) inhibitor with an IC50 value of 3.9 μM. Sarcophine is a nature product that could be isolated form the Red Sea soft coral Sarcophyton glaucum.
    Sarcophine
Cat. No. Product Name / Synonyms Application Reactivity